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Odevixibat, a small molecule that inhibits ileal resorption of BAs belonging to the class of ileal BAs transporter (IBAT) inhibitors, was the first drug approved for the treatment of PFIC patients 6 months old due to its efficacy on both pruritus and reduction of serum BAs as well as its good tolerability in 2021 [16]

In these cases, IV B-complex therapy may be considered as supportive care , delivered through clinical assessment and medical oversight

You can try putting a cold compress on it for a few hours and see if it helps

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However, the efficacy of PRP varies depending on patient characteristics, disease severity, and the specific administration methodology